General terms:
* Ranch: Especially for livestock (cattle, sheep, horses)
* Plantation: Often used for large farms growing a specific crop like cotton or coffee
* Estate: A large landed property, often with a mansion or manor house
* Holding: A large area of land under single ownership
* Spread: A large, expansive farm
* Latifundia: A large landed estate, often with a historical connection
More specific terms:
* Megafarm: A large, highly mechanized farm
* Factory farm: A large farm focused on intensive animal production
* Commercial farm: A large farm focused on large-scale crop production
The best word to use will depend on the specific context and the type of farming being done.